Close this search box.

Alpha Lipoic Acid Bulk Powder: Premium Quality Raw Ingredient for Supplement Brands

What is Alpha Lipoic Acid Powder

Alpha Lipoic Acid (ALA) is a naturally occurring fatty acid that is vital in converting glucose into energy using oxygen through aerobic metabolism.

alpha-lipoic acid structure

The ALA powder is chemically known as thioctic acid, and its CAS (Chemical Abstracts Service) Number is 1077-28-7. It also goes by several other names, including Thioctic acid,α-lipoic acid, Lipoic acid, Acetate Replacing Factor, Biletan, and Lipoicin.

Alpha Lipoic Acid is a yellow crystalline powder at room temperature, soluble in water, ethanol, and acetone. Its molecular weight is 206.33 g/mol, and its formula is C8H14O2S2.

Natural Sources of alpha lipoic acid

Here are some common food sources of alpha-lipoic acid:

Alpha Lipoic Acid powder natural source
Food SourceAmount of Alpha-Lipoic Acid
Spinach0.28-0.43 mg per 100g
Broccoli0.15-0.45 mg per 100g
Tomatoes0.19-0.27 mg per 100g
Potatoes0.14-0.26 mg per 100g

Forms of ALA Powder

ALA powders are popular in the forms of general Alpha lipoic acid powder, R-Lipoic Acid powder, R-Alpha-Lipoic Acid Tromethamine Salt, and other sodium forms such as Alpha Lipoic Acid Sodium (ALA-Na) and R-alpha-Lipoic acid sodium(R-ALA-Na).

Alpha Lipoic Acid Powder

Alpha lipoic acid powder is a versatile and easy-to-use form of this antioxidant supplement. This powder can be easily mixed with water, or juice, or added to a smoothie to suit your needs. Its potential benefits include promoting cardiovascular health, maintaining healthy blood sugar levels, and supporting liver health.

R-Lipoic Acid Powder

The alpha lipoic acid (ALA) is available in different forms, including R-lipoic acid, a naturally occurring type of ALA. It can be found in the following specifications:

  • CAS Number: 1200-22-2
  • Other names: (R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
  • Formula: C8H14O2S2

R-lipoic acid is the active form of ALA and is thought to be bioavailable and more efficiently absorbed by the body than other forms of ALA, but its stability and high cost are not so user-friendly.

R-Alpha-Lipoic Acid Tromethamine Salt

R-Alpha-Lipoic Acid Tromethamine Salt is another form of ALA having unique specifications:

  • CAS Number: 14358-90-8
  • Other names: 2-Amino-2-(hydroxymethyl)propane-1,3-diol 5-(1,2-dithiolan-3-yl)pentanoate
  • Formula: C8H14O2S2·C4H11NO3

This form of ALA is specifically designed to improve its stability and solubility, making it more readily available for absorption and utilization in the body.

ALA Sodium Forms

Other sodium forms of ALA are available, which show improved bioavailability due to increased solubility in water. These include:

ALA sodium derivativesCas number
Alpha Lipoic Acid Sodium2319-84-8
R-alpha-Lipoic acid sodium176110-81-9

These sodium forms of ALA are specifically designed to maximize absorption and provide enhanced benefits in the body.

Ultimately, choosing which alpha-lipoic acid powder to use will depend on your needs and preferences.

Alpha Lipoic Acid Vs. R-Lipoic Acid, Which Is Better?


Alpha Lipoic Acid (ALA) and R-Lipoic Acid (RLA) are antioxidants that can help reduce inflammation and promote overall health. They share the same chemical structure and are isomers, meaning they have the same atoms but differ in how they are arranged in space.

In supplements, ALA often contains a 50/50 mix of R-Lipoic Acid and its less effective counterpart, S-Lipoic Acid.


ALA is more widely available in the market, primarily because it is cheaper to produce. RLA, on the other hand, is less common and can be harder to find due to its higher production costs.


Of the two isomers, R-Lipoic Acid is considered more potent and effective in reducing oxidative damage and inflammation. It is more effective than the 50/50 mixture of R and S isomers found in ALA. This can be important for those seeking the greatest impact from their supplement.


In terms of stability, liquid formulations of R-Lipoic Acid are better absorbed and more stable in the bloodstream than the solid form found in many ALA supplements. This can result in greater efficacy, especially in managing conditions like diabetic neuropathy.


As mentioned earlier, ALA is generally more affordable due to the lower cost of S-Lipoic Acid than R-Lipoic Acid. This makes ALA a more budget-friendly option for those who want to incorporate lipoic acid into their supplement regime.

ALA (Thioctic acid), R-ALA, Which Is Better?

When choosing between ALA and RLA, the decision depends mainly on your individual needs and preferences. If you’re focused on potency and absorption, R-Lipoic Acid may be a better choice. However, if you’re more concerned about affordability and accessibility, Alpha Lipoic Acid may be the way to go.

Alpha Lipoic Acid Powder Manufacturing Process

Raw Materials Used

The manufacturing process of alpha lipoic acid powder involves using a raw material called 6,8-dichlorooctanoic acid ethyl ester. This raw material is essential for producing high-quality alpha lipoic acid powder.

Simple Steps

Here’s a brief overview of the steps involved in manufacturing alpha lipoic acid powder:

  1. Synthesis: 6,8-dichlorooctanoic acid ethyl ester is reacted with a sulfur-containing compound such as hydrogen sulfide to produce alpha-lipoic acid.
  2. Filtration: The reaction mixture is then filtered to remove any impurities and solid particles.
  3. Purification: The filtered mixture is purified using methods such as chromatography or recrystallization. This step separates alpha-lipoic acid from other compounds in the mixture.
  4. Concentration: The purified alpha-lipoic acid is then concentrated by evaporating the solvent.
  5. Drying: The concentrated alpha-lipoic acid is dried to remove any remaining moisture.
  6. Purity testing: The final product is tested for purity using methods such as high-performance liquid chromatography (HPLC) or gas chromatography (GC).

Quality Control

Premium quality alpha lipoic acid powders are manufactured using a solvent-free process, ensuring purity and safety for consumers. Quality control measures are in place at every stage of the manufacturing process to maintain the high standards expected of this naturally occurring antioxidant compound.

As one of the Manufacturers of alpha lipoic acid powder, Cima Science adheres to strict guidelines and protocols, following Good Manufacturing Practices (GMP) to guarantee the final product’s purity and quality. The production facilities perform comprehensive testing and analysis to ensure the alpha lipoic acid powder meets all necessary safety standards and specifications before it is supplied to supplement brands and other industries like cosmetics and food processing.

Health Benefits of α-lipoic Acid

Alpha-lipoic acid (ALA) is a powerful antioxidant naturally produced in your body and found in various foods. Supplementing with alpha-lipoic acid powder offers numerous health benefits, including:

1. Improved Blood Sugar Control

ALA has been shown to reduce insulin resistance and enhance your body’s ability to use its own insulin, which can help lower blood sugar levels in people with type 2 diabetes. A 2018 review of 20 randomized controlled trials also demonstrated its potential to manage type 2 diabetes and metabolic disorders.

2. Support for Nerve Health

Alpha-lipoic acid may help ease nerve damage symptoms and lower the risk of diabetic retinopathy by protecting cells and neurons involved in hormone production.

3. Antioxidant Benefits

ALA is known for increasing the body’s use of glutathione, an essential antioxidant. As a strong antioxidant, it also fights against free radicals, thereby protecting your cells from damage.

Where to Buy Alpha Lipoic Acid Powder in Bulk?

CIMA Science is a leading natural ingredient manufacturer from China, specializing in providing high-quality products for various industries. As a trusted supplier, OEM, and factory, they offer a wide range of natural and nutritional ingredients to meet your needs, including alpha lipoic acid powder.

Advantages of Buying Alpha Lipoic Acid Powder from Cima Science

  • High purity up to 99%
  • Wholesale price
  • Third-party lab testing
  • Ready inventory in 1kg/bag and 25kg/drum packaging

When you purchase alpha lipoic acid powder from CIMA Science, you’re opting for a high-quality product with several key advantages. Their alpha lipoic acid powder features a high purity level of up to 99%, ensuring you receive a premium product. Additionally, their competitive wholesale pricing ensures that you’re getting the most value for your money.

CIMA Science is committed to quality assurance and conducts third-party lab testing on all its products. This guarantees you a safe and reliable product that meets industry standards. Lastly, they offer a ready inventory of alpha lipoic acid powder in both 1kg/bag and 25kg/drum packaging options, making stocking up on this essential supplement ingredient convenient.

Contact us now to get a quote today.

Get a quote Immediately