Urolithin A Powder is a compound that has been gaining attention in the health and wellness industry due to its potential benefits. Found naturally in certain fruits like pomegranates, Urolithin A is also produced in the human body by the gut microbiota when it metabolizes ellagitannins, a type of polyphenol. However, the compound can also be synthesized as a supplement in powder form for those who are interested in its health properties.
Research has shown that Urolithin A possesses various health-promoting properties, such as supporting cellular energy production, improving muscle strength, and enhancing endurance. This has led to its growing popularity among athletes and those looking for ways to combat age-related decline in physical performance.
Definition
Derived from ellagitannins, Urolithin A powder is a metabolite compound that is created when the gut bacteria break down these tannins. This biotransformation process occurs in the intestinal microbiota and has been associated with potential health benefits such as anti-inflammatory effects and improved mitochondrial function.
Chemical and Physical Features of Urolithin A Molecule
As a member of the benzo-coumarins or dibenzo-α-pyrones class of organic compounds, Urolithin A has a certain set of chemical and physical properties that make it an interesting subject of study for possible health applications. Some of the key features of the Urolithin A molecule include:
- Molecular formula: C13H8O4
- Molecular weight: 228.20 g/mol
- Appearance: Pale yellow to white powder
- Solubility: Soluble in water, methanol, and DMSO
- Melting point: 358.6°C at 760 mmHg
- Boiling Point: 554.8°C at 760 mmHg
These features, along with current research into Urolithin A’s potential health benefits, have led to the development of Urolithin A powder supplements that can be consumed to harness these properties in a more convenient form.
Sources and Extraction
Extraction Methods
Urolithin A is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. Different extraction methods are employed to obtain Urolithin A powder from these sources. Common techniques include solvent extraction, solid-phase extraction, and liquid–liquid extraction.
Natural Sources
Urolithin A is naturally obtained from the following food sources:
- Pomegranate juice – containing up to 811.1 mg/L
- Walnuts – rich in ellagitannins responsible for Urolithin A production
- Berries – such as raspberries, strawberries, and blackberries
Synthetic methods
Aside from the natural sources, Urolithin A can also be synthesized in the laboratory through different methods, including the use of enzyme-based reconversion of ellagic acid or its derivatives. These methods help improve the production rate and purity of Urolithin A powder.
Urolithin A Powder Manufacturing Process
Urolithin A powder is a beige to yellow powder that plays a role in human health due to its potential health benefits, such as anti-aging and muscular strength.
There are two primary methods of manufacturing Urolithin A powder, both involving chemical syntheses. These methods involve an Ullmann coupling reaction followed by a Lewis acid treatment. The final product is a highly purified urolithin A powder.
Urolithin A is primarily synthesized in laboratories and factories due to the difficulties in obtaining it naturally from ellagitannins-rich foods. Bioavailable Urolithin A is manufactured synthetically in these settings, ensuring it can be used effectively in end products like food supplements and beverages.
Some of the potential applications of Urolithin A powder include incorporation into protein bars, yogurts, vitamin waters, food supplements, and other bulk powder forms. The versatility of the powder allows it to be added to a variety of products, providing consumers with easy access to this potentially beneficial compound.
Health Benefits
Urolithin A powder is a promising supplement that has been shown to positively impact several aspects of health. In this section, we will explore the benefits associated with mitophagy activation, mitochondrial health, and muscle growth.
Mitophagy Activation
One of the main health benefits of Urolithin A is its ability to activate mitophagy, a process that promotes cellular health by removing damaged mitochondria through selective autophagy. According to a study, Urolithin A enhances cellular health by increasing mitophagy, mitochondrial function, and reducing detrimental inflammation.
Mitochondrial Health
Urolithin A also plays a significant role in improving mitochondrial health. As we age, our mitochondrial function declines, leading to impaired cellular energy production. Research indicates that one of the biggest benefits of Urolithin A is its ability to boost cellular energy production in the mitochondria. By promoting mitophagy and improving the overall function of the mitochondria, Urolithin A helps combat age-related cellular decline.
Muscle Growth
Urolithin A has also been linked to improved muscle growth and function. Several preclinical studies have shown how Urolithin A can protect against age-related conditions affecting the muscles. Human trials have provided further support for this claim, showing the benefits of Urolithin A supplementation on muscle health. Improved muscle health is crucial to maintaining mobility and overall physical wellbeing as we age.
Dosage and Usage
The recommended daily dose of Urolithin A is 500mg in the form of powder, as indicated by many urolithin A supplement formulas. This dose can be mixed with yogurts, smoothies, and other breakfast favorites to incorporate it into your daily routine.
Safety and Precautions
Urolithin A has been deemed safe for consumption in food and supplement products, with studies tracking its compliance and safety among participants. However, it is always important to consult with a healthcare professional before introducing a new supplement into your regimen, particularly if you have existing health conditions or if you are currently taking any medication. Each individual’s needs may differ, and a healthcare professional can provide personalized guidance on appropriate supplementation.
As a reminder, supplements should not replace a balanced and varied diet, and it is crucial to maintain a healthy lifestyle while using Urolithin A or any other supplement to maximize its potential benefits.
Current Research
Urolithin A (UA) has been the subject of numerous research studies due to its potential impacts on health and disease. The compound is derived from ellagitannins, which can be found in various plant-based foods such as pomegranates, berries, and nuts. The gut bacteria in our bodies are responsible for breaking these ellagitannins down, ultimately producing urolithin A (PubMed).
In recent years, clinical trials have focused on the potential benefits of urolithin A supplementation for older adults. One notable study conducted in Seattle, Washington, investigated the effects of UA supplementation on muscle endurance and mitochondrial health amongst participants aged 65-90 years (PubMed). This research emphasizes the potential for urolithin A to impact aging and age-related diseases positively.
Another area of interest is the role of UA in promoting angiogenesis and tissue regeneration, especially in the context of chronic wounds. Research has shown that urolithin A plays a crucial role in skin wound healing by stimulating neovascularization and delivering essential nutrients and oxygen to the affected area (Frontiers).
There are ongoing clinical trials to study urolithin A’s potential when directly supplemented in the diet, as many people may not have gut bacteria capable of producing adequate amounts of UA from food sources alone. One such trial is registered with Nature and aims to overcome the limitations of indirect supplementation through the consumption of ellagitannin-rich foods.
In conclusion, urolithin A has garnered increased attention in recent years due to its potential health benefits and implications for aging and disease. Current research aims to understand UA’s various effects on the human body and determine optimal supplementation methods to maximize its potential benefits.
Where to Buy Urolithin A Powder in Bulk?
Cima Science is a reputable supplier of Urolithin A powder. They offer micronized Urolithin A bulk powder with 99% purity and pack their products in 25kg/drum quantities. As a reliable and professional supplier, Cima Science ensures the quality and consistency of their products, making them a top choice when looking for bulk Urolithin A powder.
Advantages of Urolithin A from Cima Science
There are several benefits of sourcing Urolithin A powder from Cima Science:
- High Purity: Their Urolithin A powder has a minimum purity of 99%, ensuring that you receive a high-quality and effective product.
- Bulk Quantities: Cima Science offers their Urolithin A powder in 25kg/drum quantities, making it suitable for both personal use and commercial manufacturing of supplements.
- Professional and Reliable: With a commitment to excellence, Cima Science is a trusted supplier that focuses on delivering consistent and reliable products.
When considering where to purchase bulk Urolithin A powder, Cima Science is an excellent option due to their dedication to quality, purity, and customer satisfaction.
Literature References
- D’Amico D, Andreux PA, Valdés P, Singh A, Rinsch C, Auwerx J. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends Mol Med. 2021 Jul;27(7):687-699. doi: https://doi.org/10.1016/j.molmed.2021.04.009 . Epub 2021 May 21. PMID: 34030963.
- Liu S, D’Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, Rinsch C, Singh A, Marcinek DJ. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jan 4;5(1):e2144279. doi: https://doi.org/10.1001/jamanetworkopen.2021.44279 . PMID: 35050355; PMCID: PMC8777576.
- Feng ZH, Chen J, Yuan PT, Ji ZY, Tao SY, Zheng L, Wei XA, Zheng ZY, Zheng BJ, Chen B, Chen J, Zhao FD. Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model. Front Pharmacol. 2022 Mar 14;13:806284. doi: https://doi.org/10.3389/fphar.2022.806284 . PMID: 35359856; PMCID: PMC8964070.
- Singh, A., D’Amico, D., Andreux, P.A. et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr 76, 297–308 (2022). https://doi.org/10.1038/s41430-021-00950-1
